Runner up would be the debut of the Douglas DC-3. This was the aircraft that introduced the concept of affordable long-haul flying, and changed the face of global air travel more than any other plane in history. The most significant flight of all time was Pan Am’s inaugural of the Boeing 747 in January, 1970. The idea of lists like these is to draw from different perspectives.įor me, the proper benchmark is less a matter of first, fastest, or highest, than a matter of scope, scale and influence. Of course, there is no single correct answer. But some of the other entries, I don’t know.